The rapid advancement of genetic technologies and DNA editing methods has brought about fundamental changes in the legal, political, social, ethical, medical, agricultural, and environmental sciences. However, the harms resulting from these innovations present unique challenges, especially in the area of ​​civil liability. This research, in a descriptive analytical manner, while examining the importance of this issue from a legal perspective, has examined the existing foundations of civil liability, including fault-based liability, liability based on the assumption of fault, strict liability (presumption of liability), and absolute liability, in order to formulate and provide a comprehensive basis for civil liability arising from DNA editing technologies. Therefore, after critically and comparative analyzing the limitations of the civil liability bases arising from DNA editing in current legal systems and identifying the existing challenges, this study seeks to propose solutions to ensure more effective accountability and provide a balanced approach. After combining legal and genetic perspectives, the findings showed that traditional foundations of civil liability are unable to fully cover long-term and intergenerational consequences, and the combination of strict liability and, in certain cases, absolute liability, as an appropriate basis, provides greater ability to manage the risks arising from genetic interventions and suggests innovative solutions to balance the long-term consequences of this technology, the protection of individual rights and public interests, with an emphasis on civil liability.